深圳大学过敏反应与免疫学研究所高薪诚聘博士后
深圳大学过敏反应与免疫学研究所杨平常教授、宋江平教授（国家杰青，北京协和医学院长聘准聘教授，深圳大学医学部兼职教授）、胡东生教授、徐大模教授、黄啸谷教授团队现因科研工作（国家自然科学基金重大项目、国家自然科学基金等）需要，现拟招聘博士后研究人员8-10名，具体要求如下：
研究方向1：心脏疾病免疫治疗2-3人；
研究方向2：医学免疫学（粘膜免疫）2-3人；
研究方向3：生物信息与分子流行病学；重大疾病综合病因学及预测预警研究；多源多维健康大数据构建与分析2-3人；
研究方向4：环境因素与过敏性疾病2人。
应聘条件（要求）：
（1）博士毕业生（含往届和应届生），外语通过六级；
（2）博士期间在核心刊物（SCI收录）发表论文1篇以上；
（3）事业心和责任心强，年龄不超过35周岁，博士毕业不超过3年。
聘期待遇：
（1）参照国家人事部博士后有关待遇执行；
（2）按深圳市政府博士后研究生资助规定，开题和中期考核合格后可向深圳市申请两期补助，每期18万元（税后）；
（3）工资和津贴：40万元以上/年（约43-50万元/年）
（4）按深圳市政府有关规定，对出站后留深工作者给予30万元科研启动经费；
（5）博士后人员进站，可自愿选择落户深圳市。选择落户深圳市的，其配偶及未成年子女可办理随迁入户。博士后子女入托、入学等按深圳市相关条例执行；
（6）出站后可优先考虑或推荐事业单位（高校或医院，尤其是留本院）工作；
（7）可以随时到心血管疾病国家重点实验室交流访问。
联系方式：
博士毕业生（含应届生）可将个人简历送给研究助理龚苗收
联系人：龚苗
手机号（同微信号）15914068577
E-mail: gm549605492@163.com
地址：广东省深圳市南山区学苑大道1066号深圳大学丽湖校区A7栋511室
邮编：518055
深圳大学过敏与免疫学研究所
2023年04月13日
博士后合作导师简介：
一、杨平常：男，医学博士、特聘教授、博导；深圳大学过敏反应与免疫学研究所所长、呼吸疾病国家重点实验室深圳大学变态反应分室主任、深圳市过敏反应与免疫学重点实验室主任。原加拿大McMaster大学病理学系副教授；主要从事免疫调节、过敏反应发病原理和免疫耐受的研究工作30年，以第一作者和通讯作者在国际主流期刊发表论文超过200篇，包括J Clin Invest, Gastroenterology, Gut, JACI, Circulation等，其中20篇影响因子>10.0分；30余篇影响因子>5.0分，文章总引用率超过5000次。主持国家重大项目、国家基金面上项目以及省市级等科研课题多项，获多项省市科技进步奖。
发表主要学术论文情况：
1．Lin J#, Huang N#, Li J#, Liu X#, Xiong Q, Hu C, Chen D, Guan L, Chang K, Li D, Tsui SK*, Zhong N*, Liu Z*, Yang PC*. Cross-reactive antibodies against dust mite-derived enolase induce neutrophilic airway inflammation. Eur Respir J, 2021;57(1):1902375.
2．Liu XY, Wu YJ, Song LJ, Zeng XH, Wang S, Liu JQ, Mo LH, Geng XR, Yang LT, Zhang XW*, Liu ZG*, Yang PC*. 3-methyl-4-nitrophenol regulates dendritic cell activities to facilitate the development of nasal allergy. J Allergy Clin Immunol. 2019;143(4):1614-1616.
3．Yang LT#, Shu Q#, Luo XQ#, Liu ZQ, Qiu SQ, Liu JQ, Guo HJ, Li LJ, Li MG, Liu DB, Xia LX, Liu ZG*, Yang PC*. Long-term effects: Galectin-1 and specific immunotherapy for allergic responses in the intestine. Allergy. 2018;73(1):106-114.
4．Liu XY, Xu LZ, Luo XQ, Geng XR, Liu ZQ, Yang LT, Yang G, Chen S, Liu ZG*, Li HB*, Yang LT, Luan TG*, Yang PC*. Forkhead box protein-3 (Foxp3)-producing dendritic cells suppress allergic response. Allergy. 2017;72(6): 908-917.
5．Yang G, Geng XR, Song JP, Wu YY, Yan H, Zhan Z, Yang L, He W, Liu ZQ, Qiu S, Liu Z*, Yang PC*. Insulin-like growth factor-2 enhances regulatory T cell functions and suppresses food allergy in an experimental model. J Allergy Clin Immunol. 2014;133(6): 1702-1708.
6．Wu W, Sun M, Zhang HP, Chen T, Wu R, Liu C, Yang G, Geng XR, Feng BS, Liu ZG, Liu Z*, Yang PC*. Prolactin mediates psychological stress-induced dysfunction of regulatory T cells to facilitate intestinal inflammation. Gut. 2014;63(12):1883-92.
7．He SH, Chen X, Song CH, Liu ZQ, Zhou LF, Ma WJ, Zhao LD, Li TL, Tang SG, Xing Z, Yang PC*. A novel interferon lambda-mediated pathway in establishment of oral tolerance and inhibition of antigen-specific Th2 polarized gut inflammation. Gastroenterology. 2011;141:249-258.
8．Zheng PY, Feng BS, Oluwole C, Struiksma S, Chen X, Li P, Tang SG, Johan D. Söderholm JD, Yang PC*. Psychological stress induces eosinophils to produce corticotrophin releasing hormone in the intestine. Gut. 2009;58:1473-9.
二、宋江平：男，医学博士，北京协和医学院长聘准聘教授（Tenure-track）, 深圳大学医学部客座教授，中国医学科学院阜外医院心脏外科五病区副主任。国家杰出青年获得者，北京杰青获得者。近年来专注心血管免疫治疗力求寻找到治疗靶点，形成转化。5年内以第一作者或通讯作者发表论文62篇，包括Circulation（IF：29.69，5篇）、Eur Heart J（IF：29.98）、Nat Cell Biol（IF：28.82）、Sci Transl Med（IF：17.96）、Basic Res Cardiol（IF：17.17）、ATVB等。
发表主要学术论文情况：
1．Chen L, Hua K, Zhang N, Wang J, Meng J, Hu Z, Gao H, Li F, Chen Y, Ren J, Liu L, Zhou Q, Gu J, Song J*, Zhang X, Hu S. Multifaceted Spatial and Functional Zonation of Cardiac Cells in Adult Human Heart. Circulation 2022, 145: 315-318.
2．Song S, Tien CL, Cui H, Basil P, Zhu N, Gong Y, Li W, Li H, Fan Q, Min Choi J, Luo W, Xue Y, Cao R, Zhou W, Ortiz AR, Stork B, Mundra V, Putluri N, York B, Chu M, Chang J, Yun Jung S, Xie L, Song J*, Zhang L, Sun Z. Myocardial Rev-erb-Mediated Diurnal Metabolic Rhythm and Obesity Paradox. Circulation 2022, 145: 448-464.
3．Rao M, Wang X, Guo G, Wang L, Chen S, Yin P, Chen K, Chen L, Zhang Z, Chen X, Hu X, Hu S, Song J*. Resolving the intertwining of inflammation and fibrosis in human heart failure at single-cell level. Basic Res Cardiol. 2021;116(1):55.
4．Chang Y, Li X, Cheng Q, Hu Y, Chen X, Hua X, Fan X, Tao M, Song J*, Hu S. Single-cell transcriptomic identified HIF1A as a target for attenuating acute rejection after heart transplantation. Basic Res Cardiol. 2021;116(1):64.
5．Ren J, Tsilafakis K, Chen L, Lekkos K, Kostavasili I, Varela A, Cokkinos DV, Davos CH, Sun X, Song J*, Mavroidis M. Crosstalk between coagulation and complement activation promotes cardiac dysfunction in arrhythmogenic right ventricular cardiomyopathy. Theranostics . 2021;11(12):5939-5954.
6．Hu Z, Liu W, Hua X, Chen X, Chang Y, Hu Y, Xu Z, Song J*. Single-Cell Transcriptomic Atlas of Different Human Cardiac Arteries Identifies Cell Types Associated with Vascular Physiology. Arterioscler Thromb Vasc Biol 2021, 41(4): 1408-1427.
7．Li HW, Hu Z, Chen X, Ren J, Cui H, Zhang M, Chen L, Hua X, Song J*, Long YT. Investigation of Lipid Metabolism in Dynamic Progression of Coronary Artery Atherosclerosis of Humans by Time-of-Flight Secondary Ion Mass Spectrometry. Anal Chem 2021, 93(8): 3839-3847.
8．Cui H, Shu S, Li Y, Yan X, Chen X, Chen Z, Hu Y, Chang Y, Hu Z, Wang X, Song J*. Plasma Metabolites-Based Prediction in Cardiac Surgery-Associated Acute Kidney Injury. J Am Heart Assoc. 2021;10(22): e021825.
9．Song JP#, *, Chen L, Chen X, Ren J, Zhang NN, Tirasawasdichai T, Hu ZL, Hua W, Hu YR, Tang HR, Chen HV, Hu SS. Elevated plasma β-hydroxybutyrate predicts adverse outcomes and disease progression in patients with arrhythmogenic cardiomyopathy. Sci Transl Med 2020, 12(530).
10．Hua X, Hu G, Hu Q, Chang Y, Hu Y, Gao L, Chen X, Yang PC, Zhang Y, Li M, Song J*. Single-Cell RNA Sequencing to Dissect the Immunological Network of Autoimmune Myocarditis. Circulation 2020, 142(4): 384-400.
11．Wang L, Yu P, Zhou B, Song J#, Li Z, Zhang M, Guo G, Wang Y, Chen X, Han L, Hu S. Single-cell reconstruction of the adult human heart during heart failure and recovery reveals the cellular landscape underlying cardiac function. Nat Cell Biol 2020, 22(1): 108-119.
12．Dai Y, Song J#, *, Li W, Yang T, Yue X, Lin X, Yang X, Luo W, Guo J, Wang X, Lai S, Andrade KC, Chang J. RhoE Fine-Tunes Inflammatory Response in Myocardial Infarction. Circulation 2019, 139(9): 1185-1198.
13．Chen L, Song J#, *, Chen X, Chen K, Ren J, Zhang N, Rao M, Hu Z, Zhang Y, Gu M, Zhao H, Tang H, Yang Z, Hu S. A novel genotype-based clinicopathology classification of arrhythmogenic cardiomyopathy provides novel insights into disease progression. Eur Heart J 2019, 40(21): 1690-1703.
14．Chen X, Zeng XH, Wang M, Chen L, Zhang N, Rao M, Yang PC, Song J*. Bcl2-Like Protein 12 Is Required for the Aberrant T Helper-2 Polarization in the Heart by Enhancing Interleukin-4 Expression and Compromising Apoptotic Machinery in CD4+ T Cells. Circulation 2018, 138(22): 2559-2568.
三、胡东生：男，理学博士，博导，教授，深圳大学公共卫生学院院长。主要研究方向为重大慢性病、传染病流行规律及创新干预策略、健康城市理论与评价、循证公共卫生决策。承担国家科技支撑及重大科技专项分课题4项，国家自然科学基金面上项目5项，发表SCI收录论文226篇（H-index归属深圳大学和郑州大学分别为16和28），主编或参编国家级规划教材及学术专著19部。教育部公共卫生与预防医学专业教学指导委员会委员，教育部国家级精品课程（流行病学）负责人，广东省高校公共卫生与预防医学专业教学指导委员会委员，中国营养学会营养与慢病控制分会副主任委员，中国医药教育协会基层医药教育专业委员会副主任委员，中华预防医学会环境卫生学分会、心脏病预防与控制分会常务委员，流行病学分会委员，深圳市卫健委首届疫情防控公共卫生专家组成员。《中华疾病控制杂志》常务编委，《中华流行病学杂志》、《中华预防医学杂志》和《卫生研究》编委。
发表主要学术论文情况：
1．Dongsheng Hu, Barbara V. Howard, Jeffrey Henderson, Thomas K. Welty, Elisa T. Lee, Kathleen A. Jablonski. Glycemic control in diabetic American Indians: Longitudinal data from the Strong Heart Study. Diabetes Care 1999; 22(11): 1802-1807.
2．Dongsheng Hu, Kathleen A. Jablonski, Yvonne H. Sparling, David C. Robbins, Thomas K. Welty, Elisa T. Lee, Barbara V. Howard. Accuracy of lipoprotein lipids and apoproteins in predicting coronary heart disease in diabetic American Indians: The Strong Heart Study. Annals of Epidemiology 2002; 12(2): 79-85.
3．Dongsheng Hu, Jing Xie, Pengyu Fu, Jing Zhou, Dongfeng Gu. Central rather than overall obesity is related to diabetes in the Chinese population: The InterASIA Study. Obesity 2007; 15(11): 2809-2816.
4．Dongsheng Hu, DahaiYu. Epidemiology of cardiovascular diseases in Asian women. Nutrition, Metabolism & Cardiovascular Diseases 2010; 20 (6): 394-404.
5．Lu Zhang, Bingyuan Wang, Chongjian Wang, Linlin Li, Yongcheng Ren, Hongyan Zhang, Xiangyu Yang, Yang Zhao, Chengyi Han, Junmei Zhou, Xinping Luo, Dongsheng Hu*. High pulse pressure is related to risk of type 2 diabetes mellitus in Chinese middle-aged females. International Journal of Cardiology 2016; 220:467-471.
6．Ming Zhang, Yang Zhao, Haohang Sun, Xinping Luo, Chongjian Wang, Linlin Li, Lu Zhang, Bingyuan Wang, Yongcheng Ren, Junmei Zhou, Chengyi Han, Hongyan Zhang, Xiangyu Yang, Chao Pang, Lei Yin, Tianping Feng, Jingzhi Zhao, Dongsheng Hu*. Effect of dynamic change in body mass index on the risk of hypertension: Results from the Rural Chinese Cohort Study. International Journal of Cardiology 2017; 238: 117-122.
7．Yang Zhao, Ming Zhang, Xinping Luo, Chongjian Wang, Linin Li, Lu Zhang, Bingyuan Wang, Yongcheng Ren, Junmei Zhou, Chengyi Han, Chao Pang, Lei Yin, Tianping Feng, Jingzhi Zhao, Dongsheng Hu*. Association of 6-year waist circumference gain and incident hypertension. Heart 2017; 103(17): 1347-1352.
8．Ming Zhang, Bingyuan Wang, Yu Liu, Xizhuo Sun, Xinping Luo, Chongjian Wang, Linlin Li, Lu Zhang, Yongcheng Ren, Yang Zhao, Junmei Zhou, Chengyi Han, Jingzhi Zhao, Dongsheng Hu*. Cumulative increased risk of incident type 2 diabetes mellitus with increasing triglyceride glucose index in normal-weight people: The Rural Chinese Cohort Study. Cardiovascular Diabetology 2017; 16(1): 30. DOI: 10.1186/s12933-017-0514-x.
9．Chengyi Han, Yu Liu, Xizhuo Sun, Xinping Luo, Lu Zhang, Bingyuan Wang, Yongcheng Ren, Junmei Zhou, Yang Zhao, Dongdong Zhang, Xuejiao Liu, Ming Zhang, Dongsheng Hu*. Prediction of a new body shape index and body adiposity estimator for development of type 2 diabetes mellitus: The Rural Chinese Cohort Study. British Journal of Nutrition 2017; 118(10): 771-776.
10．Yongcheng Ren, Yu Liu, Xizhuo Sun, Bingyuan Wang, Yang Zhao, Dechen Liu, Dongdong Zhang, Xuejiao Liu, Ruiyuan Zhang, Haohang Sun, Feiyan Liu, Xu Chen, Cheng Cheng, Leilei Liu, Qionggui Zhou, Ming Zhang, Dongsheng Hu*. Chocolate consumption and risk of cardiovascular diseases: a meta-analysis of prospective studies. Heart 2019; 105(1): 49~55.
四、徐大模：男，免疫学博士，教授、博导，深圳大学医学部教授，英国哥拉斯哥大学感染免疫和炎症研究院终身高级研究员。1982毕业于吉林医学院获医学学士学位；1988 获白求恩医科大学免疫学硕士学位；1994获英国伦敦大学（King’s College, London, UK）免疫学博士学位。曾任腹部外科医生，卫生部长春生物制品研究所助理研究员，英国哥拉斯哥大学博士后研究员和研究员；研究领域是疾病的免疫调控。在过去25年里，共发表了110篇SCI研究论文，包括Nat Immunol，Nat Rev Immunol，JEM，PNAS和 JACI。总影响因子：674.98。总引用次数11014次，H-index：52。 8所大学、研究所的客座教授，受邀参加国际科学会议并做报告的次数超过20次。任多个SCI杂志的编委及特邀审稿人和基金会评委（包括英国哮喘病基金会）。
发表主要学术论文情况：
1．Brint EK*, D Xu*, H Liu, A Dunne, ANJ McKenzie, LAJ O’Neill and FY Liew. ST2 is an inhibitor of interleukin 1 receptor and Toll-like receptor 4 signaling and maintains endotoxin tolerance. Nature Immunology.2004.5:373-379.
2．Liew FY*, Xu D*, Brint EK, O'neill LA. Negative regulation of Toll-like receptor-mediated immune responses. Nat Rev Immunol. 2005. 5:446-58.
3．Xu, D., W.L. Chan, B.P. Leung, D.H. Hunter, K. Schulz, R.R. Carter, I.B. McInnes, J.H. Robinson and F.Y. Liew. Selective expression and functions of interleukin 18 receptor on T helper (Th) type 1 but not Th2 cells. J. Exp. Med. 1998. 188:1485-1492.
4．Xu, D., W.L. Chan, B.P. Leung, F.P. Huang, R. Wheeler, D. Piedrafita, J.H. Robinson and F.Y. Liew. Selective expression of a stable cell surface molecule on type 2 but not type 1 helper T cells . J. Exp. Med. 1998. 187:787-794.
5．Ashley M. Miller, Damo Xu*, Naveed Sattar, Andrew H. Baker, Iain B. McInnes and Foo Y. Liew*. IL-33 reduces the development of atherosclerosis. J. Exp. Med. 2008. 205(2):339-46.
6. Xu D*, Jiang HR, Kewin P, Li Y, Mu R, Fraser AR, Pitman N, Kurowska-Stolarska M, McKenzie AN, McInnes IB, Liew FY*.IL-33 exacerbates antigen-induced arthritis by activating mast cells. Proc Natl Acad Sci U S A. 2008. 105(31):10913-8.
7．Liu H, Komai-Koma M, Xu D* and Liew FY*. Toll-like Receptor (TLR) 2 signaling modulates the functions of CD4+CD25+ regulatory T cells. Proc Natl Acad Sci U S A. 2006. 103(18):7048-53
8．Komai-Koma M, Jones L, Ogg GS, Xu D*, Liew FY*. TLR2 is expressed on activated T cells as a costimulatory receptor. Proc Natl Acad Sci U S A. 2004. 101:3029-3034
9．Gao Xuzhu, Mousa Komai-Koma1, Bernard P. Leung, Hwee Siew Howe, Charles McSharry, Iain B. McInnes and Damo Xu*. Resveratrol modulates murine collagen-induced arthritis by inhibiting Th17 and B cell function. Ann. Rheum. Dise.2012, 71(1):129-35.
10．Dong Li, Rodrigo Guabiraba, Anne-Gaëlle Besnard, Mousa Komai-Koma, Majid S. Jabir, Li Zhang, Gerard J. Graham, Mariola Kurowska-Stolarska, Foo Y. Liew, Charles McSharry, Damo Xu*. IL-33 promotes ST2-dependent lung fibrosis by the induction of alternatively activated macrophages and innate lymphoid cells in mice. J Allergy Clin Immunol. 2014.134:1422-32.
五、黄啸谷：男，免疫学博士、教授、博导；深圳大学医学部教授，台湾卫生研究院环境医学研究所特聘研究员，美国约翰霍普金斯大学医学院哮喘和过敏反应中心终身教授。主要从事基因和环境因素在过敏性疾病的发病机制研究。主持国家级科研项目多项，在国际期刊发表200余篇，包括Nature Medicine, Blood, J Exp Med, J Immunol, JACI 等期刊。总引用次数10653，H 指数: 54。获省市科技进步二等奖各1项。
发表主要学术论文情况：
1．Wang LT, Lin MH, Liu KY, Chiou SS, Wang SN, Chai CY, Tseng LW, Chiou HC, Wang HC, Yokoyama KK, Hsu SH, Huang SK*. WLS/wntless is essential in controlling dendritic cell homeostasis via a WNT signaling-independent mechanism. Autophagy. 2021; 1-16.
2．Xu D, Huang SK*. IL-33: a key player in the development of iron-recycling red pulp macrophages. Cell Mol Immunol. 2020;17(12):1218-1219.
3．Suen JL, Wu TT, Li YH, Lee CL, Kuo FC, Yan PS, Wu CF, Tran M, Wang CJ, Hung CH, Wu MT, Chan MWY, Huang SK*. Environmental Factor-Mediated Transgenerational Inheritance of Igf2r Hypomethylation and Pulmonary Allergic Response via Targeting Dendritic Cells. Front Immunol. 2020;11:603831.
4．Wang HC, Wong TH, Wang LT, Su HH, Yu HY, Wu AH, Lin YC, Chen HL, Suen JL, Hsu SH, Chen LC, Zhou Y, Huang SK*. Aryl hydrocarbon receptor signaling promotes ORMDL3-dependent generation of sphingosine-1-phosphate by inhibiting sphingosine-1-phosphate lyase. Cell Mol Immunol. 2019;16(10):783-790.
5．Chen LC, Tseng HM, Kuo ML, Chiu CY, Liao SL, Su KW, Tsai MH, Hua MC, Lai SH, Yao TC, Yeh KW, Wu AH, Huang JL, Huang SK*. A composite of exhaled LTB4, LXA4, FeNO, and FEV1 as an "asthma classification ratio" characterizes childhood asthma. Allergy. 2018;73(3):627-634.
6．Zhou Y, Do DC, Ishmael FT, Squadrito ML, Tang HM, Tang HL, Hsu MH, Qiu L, Li C, Zhang Y, Becker KG, Wan M, Huang SK*, Gao P*. Mannose receptor modulates macrophage polarization and allergic inflammation through miR-511-3p. J Allergy Clin Immunol. 2018;141(1):350-364.
7．Lee CL, Huang HC, Wang CC, Sheu CC, Wu CC, Leung SY, Lai RS, Lin CC, Wei YF, Lai IC, Jiang H, Chou WL, Chung WY, Huang MS, Huang SK*. A new grid-scale model simulating the spatiotemporal distribution of PM2.5-PAHs for exposure assessment. J Hazard Mater. 2016;314:286-94.
8．Zhou YF, Kawasaki H, Hsu SC, Plunkett B, Lee RT, Yang KD, Lee YC, Huang SK*. Oral tolerance to food-induced systemic anaphylaxis mediated by the C-type lectin SIGNR1. Nature Medicine. 2010; 16:1128-1133.